Anti-Human SLC1A5 Recombinant Antibody (TAB-1010CLV)
CAT#: TAB-1010CLV
This product is a chimeric antibody against ASCT2. The anti-ASCT2 antibody specifically binds system asc amino acid transporter 2.
Tested Data
Gene Expression
FC
Figure 1 Anti-Human SLC1A5 Antibody (TAB-1010CLV) in FC
Flow cytometry analysis of HT29 cells with purified antibody TAB-1010CLV (QCAb241, Blue). Cells were blocked with Human TruStain FcXTM and washed with 0.5% BSA-PBS. Cells were then incubated with TAB-1010CLV (5 μl/5x10^5 cells) for 60 min at 4°C. The secondary antibody was FITC anti-human IgG antibody (3 μl) for 60 min at 4°C.
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Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35239/373_G10_1_selected.jpg
Normal Tissue
Figure 2 Salivary gland
High expression in salivary gland
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_B_3_1_val_selected.jpg
Normal Tissue
Figure 3 Epididymis
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_2_6.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_9_8.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_9_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105281-SLC1A5
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Specifications
- Host Species
- Human
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Applications
- FC, ADCC, CDC
- Related Disease
- Cancer
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, ADCC and CDC.
Target
- Alternative Names
- SLC1A5; solute carrier family 1 (neutral amino acid transporter), member 5; R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1; neutral amino acid transporter B(0); ATB(0); RD114 virus receptor; baboon M7 virus receptor; neutral amino acid transporter B; solute carrier family 1 member 5; RD114/simian type D retrovirus receptor; sodium-dependent neutral amino acid transporter type 2
- Gene ID
- 6510
- UniProt ID
- Q15758
REVIEWS AND Q&AS
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Customer Review
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Reliable and Consistent Results
I am very impressed with the consistency this antibody provides across multiple experiments. The repeatability of results contributes massively to the reliability of our ADCC studies focused on immune response modulation in cancer cells. The batch-to-batch consistency is one of the best features, saving our team valuable time and effort.
Enhanced Research Capabilities
The antibody's sensitivity and specificity have significantly enhanced my research capabilities, especially in flow cytometry applications. High-affinity binding combined with reduced noise levels ensures clarity in our results related to SLC1A5's role in nutrient transport, which is pivotal for understanding tumorigenic processes.
Adept in Metabolic Studies
Using the Anti-Human SLC1A5 Recombinant Antibody has greatly facilitated our metabolic studies. Its excellent specificity helps in accurately assessing the involvement of SLC1A5 in amino acid transport within cancer cells. Such detail allows us to potentially identify new intervention points for disrupting cancer cell nutrient intake.
Q&As
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What are the primary applications of the Anti-Human SLC1A5 Recombinant Antibody in research?
A: The Anti-Human SLC1A5 Recombinant Antibody is primarily used in cancer research, particularly in understanding how SLC1A5, a neutral amino acid transporter, contributes to cancer cell metabolism and growth. It has applications in flow cytometry, antibody-dependent cellular cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC) assays, aiding in analyzing cellular responses and interactions tied to SLC1A5's functionality in tumor cells.
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What makes this antibody specific in targeting SLC1A5?
A: This antibody exhibits high specificity for the human SLC1A5 transporter, ensuring accurate binding to its target. This specificity facilitates detailed studies of its expression and function in various tissue types, particularly those with elevated SLC1A5 levels, like many tumor tissues. The chimeric nature (mouse/human) ensures reduced immunogenicity in human studies.
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In what tissues is SLC1A5 predominantly expressed, and why is this important?
A: SLC1A5 is predominantly expressed in tissues such as the salivary gland, colon, epididymis, and certain cancerous tissues. This expression pattern highlights its physiological and pathological roles, where it may contribute to nutrient absorption and cellular proliferation in both healthy and cancerous states, offering insights into tissue-specific function and pathology.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-1010CLV, RRID: AB_3111807)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
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| CAT | Product Name | Application | Type |
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| TAB-1009CLV | Anti-Human SLC1A5 Recombinant Antibody (TAB-1009CLV) | FC, ADCC, CDC, Inhib | Chimeric antibody (mouse/human) |
| TAB-1011CLV | Anti-Human SLC1A5 Recombinant Antibody (TAB-1011CLV) | FC, ADCC, CDC | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
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| HPAB-N0245-YC-S(P) | Human Anti-SLC1A5 Recombinant Antibody; scFv Fragment (HPAB-N0245-YC-S(P)) | Cyt, FC, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
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| HPAB-N0245-YC-F(E) | Human Anti-SLC1A5 Recombinant Antibody; Fab Fragment (HPAB-N0245-YC-F(E)) | Cyt, FC, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
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| VS-0924-YC150 | Human Anti-SLC1A5 Recombinant Antibody Hexamer (VS-0924-YC150), CDC Enhanced | Cyt, FC, CDC | Antibody hexamer |
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| CAT | Product Name | Application | Type |
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| VS-0325-XY2087 | Anti-SLC1A5 Immunohistochemistry Kit | IHC | |
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| CAT | Product Name | Application | Type |
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| VS-0425-YC280 | Recombinant Anti-SLC1A5 Vesicular Antibody, EV Displayed (VS-0425-YC280) | ELISA, FC, Cell-uptake |
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